Cell Research

Human dendritic cells originated from hematopoietic stem cells (hemopoieticstemcell). DC source of two ways: ① myeloid stem cells in the GM-CSF stimulated to differentiate into DC called myeloid DC (myeloid dendritic cells, the MDC), also known DCl, monocytes and granulocytes have a common precursor cells; Langerhans cells (Langerhans cells, LCs), the mesothelial (or dermal) DCs, and monocyte-derived DCs ② derived from lymphoid stem cells, known as lymphoid the DC (Lymophiod dendritic cells, LDC ) or plasmacytoid DC (plasmacytoid dendritic cells, pIX ;), i.e., DC2, and a common precursor cells of T cells and NK cells. Although the number of dendritic cells (DC) less than 1% of peripheral blood mononuclear cells, but the surface has a rich antigen presenting molecules (MHC-Ⅰ and MHC-II), co-stimulatory factor the (CD80/B7-1 CD86 / B7-2, CD40, CD40L, etc.) and adhesion factor (ICAM-1, ICAM-2, ICAM-3, LFA-1, LFA-3, etc.), is a powerful professional antigen presenting cells (APC). DC has its own the immunostimulatory ability, found the only way to activate naive T cells are not sensitized APC.