Beeplog.de - Kostenlose Blogs Hier kostenloses Blog erstellen    Nächstes Blog   

Cell Research

About Cell Research



Dienstag, 11. September 2012

Biological functions of FGF21 fibroblast growth factor 21 in mouse embryonic cells

Von biomichael825, 04:57
FGF-21 biological functions mainly as the metabolic regulation hungry, but also start a major regulator of ketone body production factor. Studies have shown that patients with a variety of diseases, including diabetes, blood levels of FGF-21 significantly increased. Long-term fasting induced mouse liver expression of FGF-21 protein by peroxisome proliferator-activated receptor (PPAR) alpha pathway significantly with peripheral FGF-21 levels, and thus promote adipose tissue lipolysis and fatty acid to The outer periphery of release of fatty acids in the liver and then absorbed and converted to ketones. Another study shows that the role of FGF21 fibroblast growth factor 21 may be assisted by inducing PPAR-γ activation factor (PGC) 1α to complete, which can stimulate liver gluconeogenesis, fatty acid oxidation and ketone body production. Recent studies have shown that, FGF-21 can induce liver secretes pancreatic lipase. Liver pancreatic lipase will be a substantial increase in the metabolic state of low energy, so the FGF-21 that may be involved in the regulation of the metabolic state of low energy. FGF-21 transgenic mice were fasted for 24 hours into the metabolic state of the low-energy, generate large amounts of ketones, and normal mice do not. In addition, FGF21 fibroblast growth factor 21 transgenic mice petite, weighing only 40% to 50% of the normal mice. Hunger mainly by the growth hormone / insulin-like growth factor 1 (GH/IGF-1) way to inhibit the growth and FGF-21 can be activated by reducing the signal transduction and transcription factor (STAT) 5 activation to significantly reduce serum IGF content Therefore, FGF-21 in the state of hunger by inhibiting the growth to save energy. Thiazole TZDs (TZD) can induce db / db mice white fat and 3T3-L1 fat cells FGF-21 The expression. Rosiglitazone and pioglitazone increase insulin sensitivity through PPAR-γ, and white adipose PPAR-γ can induce FGF-21 expression, therefore TZD FGF-21 may play a role. Interestingly, the existence of circadian rhythm: FGF-21 The expression of PPAR-α ligands injected mice night bezafibrate can significantly induced the FGF-21 expression, while the daytime injection does not appear to the performance. Meanwhile, such a regulatory role in the PPAR-α knockout mice did not show that induced the expression of FGF-21 circadian bezafibrate is effected by circadian reactive liver PPAR-α system to determine. Human FGF-21 has been reported. Fasted for 7 days after the blood content of FGF-21 increases, and in patients with hypertriglyceridemia vivo FGF21 fibroblast growth factor 21 content 2 times higher than normal, and will further increase after taking fenofibrate. These data show that fasting can induce the expression of the human FGF-21, which may be regulated by PPAR-α. Other studies have shown that obesity and type 2 diabetes in patients with FGF-21 levels were significantly increased, and fat, insulin and triglyceride levels were positively correlated, but negatively correlated with high density lipoprotein. In addition, the FGF-21 mRNA expression in subcutaneous fat and blood content of FGF-21 significantly correlated prompted adipose tissue may be one of the main source of the blood FGF-21. Recent studies show that non-alcoholic fatty liver disease, chronic kidney disease and coronary heart disease in patients with blood FGF-21 levels were also significantly elevated.