Cell Research

Numerous sequence-specific transcription factors (transcription factors, TFs) a combination of cross-regulatory network, these regulatory networks constitute the basis of the cells play a biological function. On September 5, the internationally renowned journal Cell Online published an article entitled Circuitry and Dynamics of the Washington University researchers transcription factor regulation network loop dynamics and organization of Human Transcription Factor Regulatory Networks research papers, reports principles. The researchers used genome in vivo DNaseI footprinting, 475 sequence-specific transcription factor found in 41 different cells and tissues, and then analyze the dynamics of these linkages. The study found that the transcription factor network with a high degree of cell selectivity, cell selectivity is driven by several factors, including in the control of cell identity unrecognized regulon. And, also identified a variety of widely expressed factors affect the transcriptional regulatory network. Shocking, the Although transcription factors inherent diversity, independent regulatory networks of all cell types converge with neural network like life. This study provides extensive description of the transcription factor regulatory network loop dynamics and organizational principles.