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Cell Research

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Dienstag, 04. September 2012

Bone marrow mesenchymal stem cells

Von biomichael825, 11:52
The bone marrow mesenchymal stem cells (mesenchymal stem cells, MSC) is an important member of the family stem cells, derived from the development of the early mesoderm and ectoderm. MSC was originally found in the bone marrow, increasing people's attention because it has multiple differentiation potential, hematopoietic support and promote the implantation of stem cells, immune regulation and self-replication. Such as mesenchymal stem cells under the particular inducing conditions in vivo or in vitro, can differentiate into fat, bone, cartilage, muscle, tendon, ligament, nerve, liver, cardiac, endothelial and other tissue cells, continuous passage culture and cryopreservation still has multiple differentiation potential, can be used as an ideal seed cells for aging and lesions caused by tissue and organ damage repair. Bone marrow mesenchymal stem cells because of its wide range of sources, easy isolation and culture, and has strong differentiation potential and advantages of autologous transplantation, more and more scholars of all ages, is considered to be soon be introduced optimal clinical treatment stem cells . Mesenchymal stem cells in the bone marrow has the following advantages: Have a strong proliferation capability and multilineage differentiation potential, not only to differentiate into hematopoietic cells in a suitable in vivo or in vitro environments, and also having the differentiation of muscle cells, liver cells, osteoblasts, chondrocytes, and stromal cells variety the ability of the cells. Two immunomodulatory functions through the interaction between the cells and the to produce cytokines inhibit T cell proliferation and immune response, thus play the function of the immune reconstitution. Three. Has a convenient source of easy separation, culture, amplification and purification the multiple passages amplification still has the characteristics of stem cells, there is no immune rejection characteristics.