Cell Research

According to the American physicist organizational networks reported on June 29, U.S. scientists found cytokines SAMHD1 protein inhibition mechanism of bone marrow cells infected with HIV (the AIDS virus), new research extends the people how to evade the immune system of AIDS patients how to deal with HIV and HIV the understanding of the immune response in order to find to prevent HIV infection or to prevent the new therapies for its replication in the infected individuals. The research is published in the June 30 issue of Nature magazine. Bone marrow cells are the antigen a subset of the white blood cells, the immune response against viruses and other pathogens is very important for the body. Jack Scott the Jaworski's research team at Case Western Reserve University School of Medicine, AIDS Research Center and the Stowers Institute for Medical Research in the United States, Michael Walsh led a team SAMHD1 protein that senses such as macrophages and dendritic cells and bone marrow cells infected with HIV-1 virus (HIV divided into type 1 and type 2, type 1 is the main strains of the global epidemic of type 2 only popular in West Africa) and other immunodeficiency virus copies of the virus and prevent synthesis in these cells, thereby inhibiting the HIV virus. Previously, scientists have always thought that, SAMHD1 mutation can cause symptoms called AGS and symptoms of congenital infection, to be attributed to the absence of the virus, the immune system interferon inappropriate induction. Therefore, SAMHD1 and other the initiator the AGS cell proteins can abandon the nucleic acid fragments of the cells, and the prevention of such interferon system is activated inappropriately.