Cell Research

Traumatic hemorrhage is stopped by a hemostatic plug formation, is from a complicated nonlinear and space heterogeneous network proteolytic enzyme biochemical called blood coagulation. We study the spatial dynamic thrombin, the enzyme this network, by developing a fluorogenic substrate to establish methods and space to solve imaging time, thrombin enzyme activity. Clotting stimulation, immobilized tissue factor induced localized clotting enzyme activities of the impulse, in space propagation, have all the characteristics of a tourist excitation wave: constant space velocity, constant amplitude and ignore the initial stimulus once more than activation threshold value. This wave parameters by phospholipid availability or platelet, wave not form in the plasma from type A hemophiliac factors or C lack of viii and XI, the two main mediators condensation positive feedback. Stimulation of the negative feedback of protein C ways and thrombomodulin produce nonstationary model of wave form followed by reduction and destruction. This suggests that the blood can be used as an emotional media, in tourism wave after wave of solidification.