Cell Research

This study is to evaluate the relationship between the organization and the patient's prognosis BMP7 expression in hepatocellular carcinoma (HCC). BMP7 mRNA expression in liver cell carcinoma characteristics is the use of real time PCR and 30 double fresh frozen liver cell carcinoma tissues and the corresponding not cancerous tissue. BMP7 protein expression in liver cell carcinoma is confirmed using immunohistochemistry in tissue microarray. Finally, BMP7 expression and routine clinical pathology characteristic and the prognosis of patients with hepatocellular carcinoma (HCC). BMP7 mRNA expression and protein in liver cancer cell is far higher than normal liver cells. Our results show that high expression BMP7 in liver cell carcinoma on tumor size (p < 0.001), tumor cell differentiation (p = 0.041), serum AFP (p = 0.007), and tumor stage (p < 0.001). Kaplan meier survival analysis showed that a high expression levels of BMP7 lead to obvious liver cell carcinoma patients prognosis. Multivariate analysis showed that BMP7 expression level is an independent prognostic parameters on the overall survival rate for patients with hepatocellular carcinoma. These findings provide evidence shows that a high expression levels of BMP7 as a specific biomarker for the prognosis of patients with hepatocellular carcinoma (HCC) bad. Therefore, we speculate that may be a potential target BMP7 antiangiogenic therapy of liver cancer.