Cell Research

With the presence of protein RalA and RalB ,cells replicate in the form of promoting cancer invasiion. However, until now, no studies have investigated in the impact of RAL proteins on human cancer, which is very important for the development of drugs targeting these proteins. Recently, a study published in Cancer Research journal stated clearly that the presence of protein RalA and RalB is related to tumor invasion. However,Dan Theodorescu, the author of the paper from Cancer Center University in Colorado, said that the presence or absence of these proteins are not character to predict the invasive cancer. RalA and RalB will lead to a cascade changes of oncogene (gene expression). Theodorescu and his colleagues found markers of these changes, upregulation and down-regulation can predict invasive cancer.Theodorescu said that RAL protein does not promote cancer development, but RAL proteins will lead to genetic changes and thus drive cancer development. Theodorescu state that enzyme RAL of GTP family is RAS oncogene family members currently known. These GTP enzymes of Ras family are present in leukemia, lung cancer, colon cancer and other types of cancer.Researchers have been trying to find a specific target for cancer therapy. And we believe that the RAL family is a good therapeutic target of cancer.